Zanka, k., Kawaguchi, Y., Nagaoka, S.: Epigallocatechin gallate induces up-regulation of LDL receptor via the 67 kDa laminin receptor-independent pathway in HepG2 cells. Mol. Nutr. Food Res. e1901036 (2020)
Banno, A., Wang, J., Okada, K., Mori, R., Mijiti, M., Nagaoka, S.: Identification of a novel cholesterol-lowering dipeptide, phenylalanine-proline (FP), and its down-regulation of intestinal ABCA1 in hypercholesterolemic rats and Caco-2 cells. Sci. Rep. 9, 19416 (2019)
Sakakibara, T., Sawada, Y., Wang, J., Nagaoka, S., Yanase, E.: Molecular mechanism by which tea catechins decrease the micellar solubility of cholesterol. J. Agric. Food Chem. 67, 7128-7135 (2019)
Kubota, S., Tanaka, Y. and Nagaoka, S.: Ellagic acid affects mRNA expression levels of genes that regulate cholesterol metabolism in HepG2 cells. Biosci. Biotechnol. Biochem., 83, 952-959 (2019)
Maihemuti Mijiti, Wang Jilite, Huang Bingyu, Satoshi Nagaoka：A novel peptide derived from rice α-globulin decreased cholesterol micellar solubility in vitro and inhibited cholesterol absorption in rats. 13th Asian Congress of Nutrition 2019 (2019) (Indonesia)
Satoshi Nagaoka: Identification of a novel cholesterol-lowering dipeptide (FP), and its down-regulation of intestinal ABCA1 in hypercholesterolemic rats. 12th International Conference and Exhibition on Nutraceuticals and Functional Foods (ISNFF2019) 2019.12.3 (Kobe)
Wang, J., Shimada, M.and Nagaoka, S.: Identification of the active protein in rice bran protein having an inhibitory activity of cholesterol micellar solubility. Biosci. Biotechnol. Biochem., 81(6), 1216-1219 (2017)
Kitamura,K., Okada,Y., Okada,K., Kawaguchi,Y. and Nagaoka,S.:Epigallocatechin gallate induces an up-regulation of LDL receptor accompanied by a reduction of PCSK9 via the annexin A2-independent pathway in HepG2 cells. Mol. Nutr. Food Res., 61(8).(2017)
Takumi Sakakibara, Kazuki Ogawa, Satoshi Nagaoka, and Emiko Yanase:Interaction between Bile Acid and Tea Catechins Inhibits Micellar Cholesterol Solubility.International Symposium on Natural Medicines 2017, Bogor, Indonesia, August 24-25 (2017)
Nagaoka, S.: Hypocholesterolemic Pentapeptide Lactostatin (IIAEK) Activates Cholesterol Degradation via Hepatocyte Nuclear Factor 3α in HepG2 cells. The 10th International Conference and Exhibition on Nutrceuticals & Functional Foods（ISNFF 2017）（Gunsan, Korea）2017.10.24
Ogawa, K., Hirose, S., Nagaoka, S. and Yanase, E.: Interaction between tea polyphenols and bile acid inhibits micellar cholesterol solubility. J. Agric. Food Chem. 64, 204-209 (2016)
Wang, J., Shimada, M. and Nagaoka, S.: Identification of the active proteins in rice bran having an inhibitory activity of cholesterol micellar solubility. International conference on rice bran oil, Abstract p.136 (2016)（Tokyo）
Nagaoka, S.: Exhaustive analysis of a novel bile acid binding peptide derived from soybean protein and efficient modification of soystatin by peptide array, The 107 th American oil Chemist's Society Meeting & Expo (2016)（Salt Lake City, USA）2016.5.4
Ogawa, K., Hirose, S., Yamamoto, H., Shimada, M., Nagaoka, S. and Yanase, E.:Synthesis of oolongtheanins and their inhibitory activity on micellar cholesterol solubility in vitro. Bioorg. Med. Chem. Lett. 25: 749-752 (2015)
Wang, J., Shimada, M., Kato, Y., Kusada, M. and Nagaoka, S.: Cholesterol-lowering effect of rice bran protein containing bile acid-binding proteins.Biosci. Biotechnol. Biochem. 79, 456-461 (2015)
Asai, S., Kashima, Y., Kanematsu, S., Kusada, M., Watanabe, S., Kawashima, T. Nakamura, T., Shimada, M., Goto, T. and Nagaoka, S.: Major royal jelly protein 1 (MRJP1) is a novel hypocholesterolemic protein derived from royal jelly, ACN2015 Abstracts 236, 2015 (Yokohama)
Sakai, Y., Komuro, A., Yamamoto, T., Shimada, M. and Nagaoka, S.: A novel hypocholesterolemic pentapeptide, lactstatin, inhibits cholesterol absorption via the suppression of ABCA1 gene expression in Caco-2 cells, ACN2015 Abstracts 236, 2015 (Yokohama)
Wang, J., Kato, Y., Shimoda, H., Shimada, M. and Nagaoka, S.: Cholesterol-lowering effect of rice bran protein containing bile acid-binding proteins. 12 th Asian Congress of Nutrition (ACN 2015), OS10-1, Abstract p.136 (2015)（Yokohama）
Nagaoka, S.: Cholesterol lowering peptides and polyphenols. "Developing New Research Excellence inNatural Science and Technology", The 1st GU-NAST International Joint Meeting (GU-NAST 2015)(2015)（Gifu）
Cabanos C., Kato N., Amari Y., Fujiwara K., Ohno T., Shimizu K., Goto T., Shimada M., Kuroda M., Masuda T., Takaiwa F., Utsumi S., Nagaoka S. and Maruyama N.: Development of a novel transgenic rice with hypocholesterolemic activity via high-level accumulation of the α' subunit of soybean β-conglycinin. Transgenic Res., 23, 609-620 (2014)
長岡 利：油脂と健康, 14, 237-242 (2014)
Niwa, M., Yoshida, S., Takamizawa, K., Nagaoka, S., Kawakubo, N., Takahashi, Y., Suzuki, Y. : Facilitation of web-based internet PBL: What is an adequate group size ? International e-Journal of Science, Medicine & Education (IeJSME) 8, 4-11 (2014)
Kashima Y., Kanematsu S., Asai S., Kusada M., Watanabe S., Kawashima T., Nakamura T., Shimada M., Goto T. and Nagaoka S.: Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly. PLoS One, 9, e105073 (2014)
Tanaka, Y., Shimada, M. and Nagaoka, S.: L-Cysteine-induced up-regulation of the low-density lipoprotein receptor is mediated via a transforming growth factor-alpha signalling pathway. Biochem. Biophys. Res. Commun., 444, 401-405 (2014)
Kitamura, K., Mishima, S., Okada, Y., Shimada, M. and Nagaoka, S.:Epigallocatechin gallate induces a reduction of PCSK9 accompanying with an up-regulation of LDL receptor in HepG2 cells. The 3rd UGSAS-GU Symposium 2014 (Gifu)
Nagaoka, S., Kitamura, K., Mishima, S. and Shimada, M.: Epigallocatechin gallate and quercetin induce a suppression of PCSK9 accompanying with an up-regulation of LDL receptor in HepG2 cells. The 27th International Conference on Polyphenols Abstracts 41-42, 2014 (Nagoya)
Nagaoka, S.: A novel hypocholesterolemic pentapeptide, lactostatin, inhibits cholesterol absorption via the suppression of ABCA1 gene expression in Caco-2 cells. 105th AOCS Annual Meeting and Expo. May, 2014 (U.S.A, San Antonio)（Invited Speaker）
Nagaoka,S.: Hypocholesterolemic and anti-obesity actions of novel food components. Frontiers in Chemical Sciences 2014, 38, 2014, Decmember, 2014 (India, Guwahati)（Invited Speaker）
Cabanos, C., Ekyo, A., Amari, Y., Kato, N., Kuroda, M., Nagaoka, S., Takaiwa, F. Utsumi, S. and Maruyama, N.: High-level production of lactostatin, a hypocholesterolemic peptide, in transgenic rice using soybean A1aB1b as carrier. Transgenic Res., 22, 621-629 (2013)
Goto, T., Mori, A. and Nagaoka, S.: Soluble soy protein peptic hydrolysate stimulates adipocyte differentiation in 3T3-L1 cells. Mol. Nutr. Food Res., 57, 1435-1445 (2013)
Hirose, M., Ando, T., Shofiqur, R., Umeda, K., Kodama, Y., Nguyen, S.V., Goto, T., Shimada, M., Nagaoka, S.: Anti-obesity activity of hen egg anti-lipase immunoglobulin yolk, a novel pancreatic lipase inhibitor. Nutr. Metab., 10, 70 (2013)
Goto, T., Saito, Y., Morikawa, K., Kanamaru, Y. and Nagaoka, S.: Epigallocatechin gallate changes mRNA expression level of genes involved in cholesterol metabolism in hepatocytes. Br.J.Nutr. 197, 769-773 (2012)
Goto, T., Horita M., Nagai, H., Nagatomo, A., Nishida, N., Matsuura, Y. and Nagaoka, S.: Tiliroside, a glycosidic favonoid, inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract. Mol. Nutr. Food Res. 56, 435-445 (2012)
Wakasa,Y., Tamakoshi,C., Ohno,T., Hirose, S., Goto, T., Nagaoka, S. and Takaiwa, F.: The Hypocholesterolemic Activity of Transgenic Rice Seed Accumulating Lactostatin, a Bioactive Peptide Derived from Bovine Milk β-Lactoglobulin. J.Agric.Food Chem.59, 3845-3850 (2011)
Takeshita,T., Okochi, M., Kato, R., Kaga, C.,Tomita, Y., Nagaoka, S. and Honda H.: Screening of peptides with a high affinity to bile acids using peptide arrays and a computational analysis. J. Biosci. Bioeng. 112, 92-97 (2011)
Nagaoka, S.: Ameliorative action of peptides on cholesterol and lipid metabolism from the viewpoint of peptide-lipid interactions. Chapter XV: Peptide-lipid interactions and functionalities, Food Proteins and Peptides: Chemistry, Functionality, and Commercialization, p.33-55 (2011)
長岡 利：ペプチドアレイによる大豆たん白質由来の新規疎水性胆汁酸結合ペプチドの網羅解析およびin vivo での作用機構解析, 大豆たん白質研究,14, 48-52 (2011)
学会発表
加島優里，兼松智，草田未央，渡邉鈴代，川島拓司，中村正，後藤剛，長岡 利：ローヤルゼリー由来Major Royal Jelly Protein 1はコレステロール代謝改善作用を発揮する，第65回日本栄養・食糧学会大会講演要旨集p.178，2011年5月14日（東京）
Inagaki, M., Nagai, S., Yabe, T., Nagaoka, S., Minamoto, N., Takahashi, T., Matsuda, T., Nakagomi, O., Nakagomi, T., Ebina, T., Kanamaru, Y.: The bovine lactophorin C-terminal fragment and PAS6/7 were both potent in the inhibition of human rotavirus replication in cultured epithelial cells and the prevention of experimental gastroenteritis. Biosci. Biotechnol. Biochem. 74, 1386-1390 (2010)
Nagaoka, S., Nakamura, A., Shibata, H., Kanamaru, Y. : Soystatin (VAWWMY), a novel bile acid-binding peptide, decreased micellar solubility and inhibited cholesterol absorption in rats. Biosci.Biotechnol.Biochem. 74, 1738-1741 (2010)
Nakade, K., Kaneko, H. Oka, T., Ahhmed, A.M., Muguruma, M., Numata, M., Nagaoka, S.: The cattle heart protein hydrolysate ameliorates hypercholesterolemia accompanying with the suppression of cholesterol absorption in rats and Caco-2 cells. Biosci. Biotechnol. Biochem. 73, 607-612 (2009)
Ikeda, I., Kudo, M., Hamada, T., Nagao, K., Oshiro, Y., Kato, M., Sugawara, T., Yamahira, T., Ito, H., Tamaru, S.,Sato, M., Imaizumi, K., Nagaoka, S., Yanagita, T.: Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats. J. Nutr. Sci. Vitaminol. 55, 252-256 (2009)
Suido, H., Takeuchi, A., Makino, T., Tanaka, T., Nagaoka, S.: Serum Cholesterol-Lowering Effects of a Broccoli and Cabbage Mixture in Rats: Comparison with Spinach, Celery, Carrot, and Tomato. In"Functional Food and Health" edited by Shibamoto, T., ACS SYMPOSIUM SERIES 993, American Chemical Society, pp454-464 (2008)
2007
Morikawa, K., Ishikawa, K., Kanamaru, Y., Hori, G., Nagaoka, S.: Effects of dipeptides having a C-terminal lysine on the cholesterol 7α-hydroxylase mRNA level in HepG2 cells. Biosci. Biotechnol. Biochem. 71, 821-825 (2007)
Nagaoka, S. : Cholesterol-lowering proteins and peptides. In "Neutraceutical Proteins and Peptides in Health and Disease" edited by Mine, Y. and Shahidi, F., TAYLOR & FRANCIS GROUP, pp.42-67 (2006)
Nagaoka, S., Fujimura, W., Morikawa, K., Nakamura, A., Kanamaru, Y., Hori, G., Yamamoto, K., Takamura, M., Oda, M., Shin, K., Lactostatin (IIAEK) and SPHP: New Cholesterol-Lowering Peptides Derived from Food Proteins. In "Dietary Fat and Risk of Common Diseases" edited by Huang, Y.-S., American Oil Chemist's Society (AOCS) Press, pp.168-185 (2006)
Xu, M., Sugiura, Y., Nagaoka, S., Kanamaru, Y.: IEC-6 intestinal cell death induced by bovine milk alpha-lactalbumin. Biosci. Biotechnol. Biochem., 69, 1082-1089 (2005)
Xu, M., Sugiura, Y., Nagaoka, S., Kanamaru, Y.: Involvement of SDS-stable higher M(r) forms of bovine normal milk alpha-lactalbumin in inducing intestinal IEC-6 cell death. Biosci. Biotechnol. Biochem., 69, 1189-1192 (2005)
Nagaoka, S., Shimizu, K., Kaneko, H., Shibayama, F., Morikawa, K., Kanamaru,Y., Otsuka, A., Hirahashi, T., Kato, T.: A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in rats. J.Nutr., 135, 2425-2430 (2005)
Nagaoka, S., Hori, G., Yamamoto, K., Yamamoto, K., Yamamoto, S.: Improvements in cholesterol metabolism induced by soypeptides with bound phospholipids. J.Nutr. 132, 604S (2002)
Yamauchi, R., Ozeki, K., Shimoyamada, M., Nagaoka, S., Kato, K.: Oxidation products of α-tocopherol on the copper-initiated peroxidation of human plasma and rat serum. Proceedings of XI Biennial Meeting of the Society for Free Radical Research International., p.497-501 (2002)
Nagaoka, S., Masaoka, M., Zhang, Q., Hasegawa, M., Watanabe, K.: Egg ovomucin attenuates hypercholesterolemia in rats and inhibits cholesterol absorption in Caco-2 cells. Lipids, 37, 267-272 (2002)
Yang, S-M., Kanamaru, Y., Shimoyamada, M., Fumiyuki, A., Nagaoka, S., Shimizu, M., Sachdev, G.P.: Human milk bile-salt-stimulated lipase is extremely reactive with the monoclonal antibody 1CF11 which recognizes a human-specific carbohydrate antigen. Biosci.Biotech.Biochem., 65, 986-989 (2001)
Yang, S-M., Yokoi, N., Kanamaru, Y., Takenaka, O., Atoji, Y., Bunai, Y., Ohya, I., Song, X-G., Nagaoka, S., Shimizu, M., Sachdev, G.P.: Unique occurrence of the 1CF11 carbohydrate epitope in primate saliva. Biosci.Biotech.Biochem., 65, 714-718 (2001)
Nagaoka, S., Futamura, Y., Miwa, K., Awano, T., Yamauchi, K., Kanamaru, Y., Kojima, T., Kuwata, T.: Identification of novel hypocholesterolemic peptides derived from bovine milk β-lactoglobulin. Biochem.Biophys.Res.Commun., 281, 11-17 (2001)
Hori, G., Wang, M.-F., Chan, Y.C., Komatsu, T., Wong, Y., Tzu-Hsiu Chen, T.-H., Yamamoto, K., Nagaoka, S., Yamamoto, S.: Soy protein hydrolyzate with bound phospholipids reduces serum cholesterol levels in hypercholesterolemic adult male volunteers. Biosci.Biotech.Biochem., 65, 72-78 (2001)
長岡 利：タンパク質から派生する生理活性ペプチド（吸収調節ペプチド）、 PEPTIDE NEWS LETTER JAPAN 37, 3-4 (2000) （総説）
Yang, S.-M, Kanamaru, Y., Ikeda, S., kaneko, T., Kuwata, T., Nagaoka, S., Shimizu, M., Sachdev, G.P.: Identification of two molecular species in human milk-derived lactoferrin, in "Lactoferrine: Structure, Function and Applications" K.Shimazaki et al., eds., Elsevier Science B.V., pp.17-25 (2000)
1999
Nagaoka, S., Miwa, K., Eto, M., Kuzuya, Y., Hori, G., Yamamoto, K.: Soyprotein peptic hydrolyzate with bound phospholipids decrease micellar solubility and cholesterol absorption in rats and Caco-2 cells. J.Nutr. 129, 1725-1730 (1999)
Morishita, K., Yamamoto, K., Hori, G., Tanaka, M., Kamiya, S., Nagaoka , S.:Cholesterol-lowering effects of soy protein peptic hydrolyzate with bound phospholipids in rats; cross-over test, dose-response test, and comparison with materials which have cholesterol-lowering effect. J.Jap.Soc.Nutr.Food Sci. 52, 183-191 (1999)
Hori, G., Yamamoto, K., Morishita, K., Mukawa, S., Kamiya, S., Nagaoka, S.: Cholesterol-lowering effects of isolated soybean protein hydrolyzate with bound phospholipids in rats. J.Jap.Soc.Nutr.Food Sci. 52, 135-145 (1999)
Pissios, P., Kan, H.Y., Nagaoka, S., Zannis, V.I.: SREBP-1 binds to multiple sites and transactivates the human apoA-II promoter in vitro. SREBP-1 mutants defective in DNA binding or transcriptional acitvativation repress ApoA-II promoter activity. Arterioscler.Thromb.Vasc.Biol. 19, 1456-1469 (1999)
